Compound Q&A

How is (4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one (CAS: 101711-78-8) typically synthesized?

Answer

(4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one
(4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one can be synthesized via the condensation of propionyl chloride with 4-benzyl-1,3-oxazolidin-2-one, using a catalytic amount of triethylamine. The reaction is typically carried out under mild conditions, and the yield is usually around 80-90%. This compound is also prepared via the hydrolysis of 4-benzyl-3-propionoyl-1,3-oxazolidin-2-one, which provides a higher yield and better purity.

About

English Name (4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one
Molecular Formula C13H15NO3
Molecular Weight 233.27 g/mol
SMILES CCC(=O)N1C(COC1=O)CC2=CC=CC=C2
InChIKey WHOBYFHKONUTMW-NSHDSACASA-N
Last Updated: 2025-10-16 16:48

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