How is Sodium [{2-[bis(carboxylatomethyl)amino]ethyl}(2-hydroxyethyl)amino]acetate hydrate (CAS: 207386-87-6) typically synthesized?

Sodium [{2-[bis(carboxylatomethyl)amino]ethyl}(2-hydroxyethyl)amino]acetate hydrate is synthesized through a multi-step process involving the reaction of sodium acetate with 2-dimethylaminoethanol and 2-aminoethanol. The reaction is typically carried out under basic conditions, and appropriate catalysts such as sodium hydroxide may be used to enhance selectivity and yield. The product is then typically isolated by filtration and dried to obtain the hydrate form.