Compound Q&A
How is [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid (CAS: 1138245-13-2) typically synthesized?
Answer
![[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid](https://static.chemtradehub.com/structs/113/1138245-13-2-8176.webp "[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid")
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid (CAS: 1138245-13-2) can be synthesized via a multi-step process involving the Wittig reaction followed by esterification. The Wittig reagent is typically prepared from the appropriate aldehyde and ethyl phosphonate, and the product is then reacted with methyl acetoacetate. The yield is generally around 70-80%, with high selectivity to the desired stereochemistry.
About
CAS No
1138245-13-2
English Name
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
Molecular Formula
C12H19NO2
Molecular Weight
209.29 g/mol
SMILES
CCC1=C[C@@H]2[C@H](C1)C[C@@]2(CC(=O)O)CN
InChIKey
FTBQORVNHOIASH-CKYFFXLPSA-N
Last Updated: 2025-10-16 16:48
![[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid — Hubei Yangxin Pharmaceutical Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cded3957537e5c8069af88/67cded3957537e5c8069af88-logo.webp){kind=logo}