Compound Q&A
How is 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile (CAS: 517918-95-5) typically synthesized?
Answer
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1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile is commonly synthesized via the reaction of 5-amino-1H-pyrrolo[2,3-b]pyridine with phosphorus tribromide followed by nitrilation. The reaction is typically carried out in a solvent like toluene, with a yield of around 80-85%. The use of a dehydrating agent like pyridine can improve the reaction selectivity and yield.
About
CAS No
517918-95-5
English Name
1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Molecular Formula
C8H5N3
Molecular Weight
17.03 g/mol
SMILES
C1=CNC2=NC=C(C=C21)C#N
InChIKey
DRAQIXNADYAISI-UHFFFAOYSA-N
Last Updated: 2025-10-13 19:39
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