Compound Q&A
How is 3-Bromo-5-(trifluoromethyl)pyridine (CAS: 436799-33-6) typically synthesized?
Answer
3-Bromo-5-(trifluoromethyl)pyridine can be synthesized through a Friedel-Crafts alkylation reaction using 2,6-dibromopyridine and trifluoroacetyl chloride. This method requires the use of a Lewis acid catalyst such as aluminum chloride (AlCl3) to facilitate the electrophilic aromatic substitution. The reaction typically gives a high yield and high selectivity.
About
CAS No
436799-33-6
English Name
3-Bromo-5-(trifluoromethyl)pyridine
Molecular Formula
C6H3BrF3N
Molecular Weight
226 g/mol
SMILES
C1=C(C=NC=C1Br)C(F)(F)F
InChIKey
HEDHNDVPKRVQPN-UHFFFAOYSA-N
Last Updated: 2025-10-13 17:50
