Compound Q&A
How is 1-(4-Carboxyphenyl)-3-methyl-5-pyrazolone (CAS: 60875-16-3) typically synthesized?
Answer
1-(4-Carboxyphenyl)-3-methyl-5-pyrazolone can be synthesized by reacting 4-chloroacetophenone with methyl isonicotinohydrazide in the presence of a base like sodium hydroxide. The reaction involves a nucleophilic substitution followed by an acid-catalyzed condensation. The yield is typically around 75-80%, and the product can be purified by recrystallization.
About
CAS No
60875-16-3
English Name
1-(4-Carboxyphenyl)-3-methyl-5-pyrazolone
Molecular Formula
C11H10N2O3
Molecular Weight
218.212 g/mol
SMILES
CC1=NN(C(=O)C1)C2=CC=C(C=C2)C(=O)O
InChIKey
CUGBBQWDGCXWNB-UHFFFAOYSA-N
Last Updated: 2025-10-13 17:50
