How is 4-Bromoisoxazole (CAS: 97925-43-4) typically synthesized?

4-Bromoisoxazole is typically synthesized by bromination of isoxazole. This can be achieved through direct bromination using bromine in the presence of a Lewis acid like aluminum bromide or through a nucleophilic substitution reaction using bromine and an appropriate base such as sodium hydroxide in an organic solvent. The yield and selectivity depend on the reaction conditions and catalysts used.