Compound Q&A

How is 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (CAS: 119006-77-8) typically synthesized?

Answer

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole is synthesized through a multi-step process involving the coupling of fluoro-phenyl derivatives with imidazole. Commonly used catalysts include palladium-based compounds. The reaction typically yields a mixture of isomers, and purification is achieved through column chromatography or recrystallization. The overall yield ranges from 60% to 80%.

About

English Name 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
Molecular Formula C22H16F2N2
Molecular Weight 346.38 g/mol
SMILES C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4
InChIKey QHMWCHQXCUNUAK-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55

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