Compound Q&A
How is 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione (CAS: 871700-24-2) typically synthesized?
Answer
![3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione](https://static.chemtradehub.com/structs/871/871700-24-2-c5dd.webp "3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione")
The compound is synthesized through a multi-step process involving aryl iodination, cyclopropylation, and pyrimidine ring formation. Commonly used catalysts include palladium complexes and base conditions such as sodium hydride. The reaction is selective and yields up to 80% purity.
About
CAS No
871700-24-2
English Name
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
Molecular Formula
C18H15FIN3O4
Molecular Weight
483.2370000000003 g/mol
SMILES
O=C1N(C2=CC=C(I)C=C2F)C3=C(C(O)=C(C)C(N3C)=O)C(N1C4CC4)=O
InChIKey
MHHFXMZMCYWCJQ-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
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