Compound Q&A
How is 1-Fluoro-4-iodo-2-methylbenzene (CAS: 452-68-6) typically synthesized?
Answer
1-Fluoro-4-iodo-2-methylbenzene (CAS: 452-68-6) can be synthesized through various methods, including the Friedel-Crafts alkylation of toluene with methyl iodide and subsequent fluorination with hydrogen fluoride. Another route involves the iodination of 1-fluoro-2-methylbenzene followed by amination using methyl iodide and ammonium nitrate. These reactions typically require mild to moderate conditions and can achieve good yields.
About
CAS No
452-68-6
English Name
1-Fluoro-4-iodo-2-methylbenzene
Molecular Formula
C7H6FI
Molecular Weight
236.03 g/mol
SMILES
CC1=C(C=CC(=C1)I)F
InChIKey
DYQIYXDSKUUZRI-UHFFFAOYSA-N
Last Updated: 2025-10-13 11:18
