Compound Q&A

How is 2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate (CAS: 26225-79-6) typically synthesized?

Answer

2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate
2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate is usually synthesized through the methylation of 2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-carboxylic acid with methanesulfonyl chloride in the presence of a suitable base. The reaction is typically carried out at room temperature with high selectivity and yields over 90%. The use of a phase transfer catalyst can further enhance the efficiency of the synthesis.

About

CAS No 26225-79-6
English Name 2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate
Molecular Formula C13H18O5S
Molecular Weight 286.349 g/mol
SMILES CCOC1C(c2cc(ccc2O1)OS(=O)(=O)C)(C)C
InChIKey IRCMYGHHKLLGHV-UHFFFAOYSA-N
Last Updated: 2025-10-13 11:18

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