Compound Q&A

How is 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 819058-34-9) typically synthesized?

Answer

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 819058-34-9) can be synthesized via a boronate esterification reaction. A typical method involves the condensation of 2-fluoroaniline with 1,3,2-dioxaborole in the presence of a palladium catalyst and a base. The reaction typically yields a high purity product with good selectivity and yield.

About

English Name 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
Molecular Formula C12H17BFNO2
Molecular Weight 237.083 g/mol
SMILES CC1(C)OB(OC1(C)C)c2ccc(N)c(F)c2
InChIKey AIXGNRNTXUKZLC-UHFFFAOYSA-N
Last Updated: 2025-10-10 21:10

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