Compound Q&A

How is 1-Methyl-1,2,3,4-tetrahydroisoquinoline (CAS: 4965-09-7) typically synthesized?

Answer

1-Methyl-1,2,3,4-tetrahydroisoquinoline
1-Methyl-1,2,3,4-tetrahydroisoquinoline is typically synthesized by a multistep process involving the condensation of 1-methylisoquinoline with formaldehyde in the presence of an acid catalyst like sulfuric acid. The yield is around 80-85%, and the reaction is selective towards the tetrahydroisoquinoline derivative.

About

CAS No 4965-09-7
English Name 1-Methyl-1,2,3,4-tetrahydroisoquinoline
Molecular Formula C10H13N
Molecular Weight 147.22 g/mol
SMILES CC1C2=CC=CC=C2CCN1
InChIKey QPILYVQSKNWRDD-UHFFFAOYSA-N
Last Updated: 2025-10-10 21:10

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