How is 1-chloro-3,5-dimethoxybenzene (CAS: 7051-16-3) typically synthesized?

1-Chloro-3,5-dimethoxybenzene (CAS: 7051-16-3) is typically synthesized through the chlorination of 3,5-dimethoxybenzene in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction involves the substitution of a chlorine atom for a hydrogen atom at the ortho position. The yield is usually high, and the selectivity towards the ortho position is good. This method provides a reliable and efficient route to the compound.