Compound Q&A
How is (3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (CAS: 78879-20-6) typically synthesized?
Answer
![(3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid](https://static.chemtradehub.com/structs/788/78879-20-6-c93d.webp "(3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid")
(3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid is synthesized via a multi-step process involving the protection of the isoquinoline ring, followed by the introduction of the 2-methyl-2-propanol moiety, and finally deprotection. Commonly used reagents include methyl 2-hydroxyacetate and 2,3-dimethyl-1,3-dioxolane. The overall yield is around 70%, and the reaction is performed under mild conditions to ensure selectivity.
About
CAS No
78879-20-6
English Name
(3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
Molecular Formula
C15H19NO4
Molecular Weight
277.32 g/mol
SMILES
CC(C)(C)OC(=O)N1CC2=CC=CC=C2CC1C(=O)O
InChIKey
HFPVZPNLMJDJFB-LBPRGKRZSA-N
Last Updated: 2025-10-10 19:08
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