How is (3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (CAS: 78879-20-6) typically synthesized?

(3S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid is synthesized via a multi-step process involving the protection of the isoquinoline ring, followed by the introduction of the 2-methyl-2-propanol moiety, and finally deprotection. Commonly used reagents include methyl 2-hydroxyacetate and 2,3-dimethyl-1,3-dioxolane. The overall yield is around 70%, and the reaction is performed under mild conditions to ensure selectivity.