Compound Q&A
How is Fosaprepitant (CAS: 172673-20-0) typically synthesized?
Answer
Fosaprepitant is synthesized through a multi-step process involving the use of Grignard reagents and Suzuki coupling reactions. The key steps include the formation of ester intermediates and the reduction of the ester to the corresponding alcohol. The final step involves the conversion to the prodrug form. The synthesis typically achieves high yields and high selectivity, making it suitable for pharmaceutical production.
About
CAS No
172673-20-0
English Name
Fosaprepitant
Molecular Formula
C23H22F7N4O6P
Molecular Weight
614.4 g/mol
SMILES
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F
InChIKey
BARDROPHSZEBKC-OITMNORJSA-N
Last Updated: 2025-10-10 19:08
