Compound Q&A
How is (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide (CAS: 1393477-72-9) typically synthesized?
Answer
![(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide](https://static.chemtradehub.com/structs/139/1393477-72-9-1cb4.webp "(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide")
This compound is synthesized through a multi-step process involving the coupling of a pyrazinyl acryloyl chloride with 3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}hydrazine. The synthesis typically uses triethylamine as a base and requires the use of a suitable solvent like dichloromethane. The overall yield is moderate, around 50-60%, with excellent selectivity.
About
CAS No
1393477-72-9
English Name
(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide
Molecular Formula
C17H11F6N7O
Molecular Weight
443.31100000000004 g/mol
SMILES
FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2ncn(/C=C\C(=O)NNc3cnccn3)n2
InChIKey
DEVSOMFAQLZNKR-RJRFIUFISA-N
Last Updated: 2025-10-10 13:51