How is (1r,1's,4r,4'R)-4-(3,4-Difluorophenyl)-4'-pentyl-1,1'-bi(cyclohexyl) (CAS: 118164-51-5) typically synthesized?

(1r,1's,4r,4'R)-4-(3,4-Difluorophenyl)-4'-pentyl-1,1'-bi(cyclohexyl) is synthesized via a multistep process involving Friedel-Crafts alkylation and ring closure. Commonly, a fluoroaromatic compound is reacted with cyclohexene in the presence of a Lewis acid catalyst. The yield and selectivity of the reaction are influenced by the choice of catalyst and reaction conditions. The process typically involves careful temperature control and use of appropriate solvents.