Compound Q&A
How is N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide (CAS: 827318-97-8) typically synthesized?
Answer
![N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide](https://static.chemtradehub.com/structs/827/827318-97-8-3731.webp "N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide")
N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide (CAS: 827318-97-8) is synthesized via a multi-step process involving the condensation of a pyrazolone derivative with an amine. The reaction typically requires a Lewis acid catalyst, such as aluminum trichloride, and proceeds with good yield under anhydrous conditions. The synthesis involves protecting groups to control the reactivity of functional groups.
About
CAS No
827318-97-8
English Name
N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide
Molecular Formula
C26H30N6O3
Molecular Weight
474.57 g/mol
SMILES
CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)C(C5=CC=CC=C5)OC
InChIKey
XKFTZKGMDDZMJI-HSZRJFAPSA-N
Last Updated: 2025-10-10 12:21
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