How is 7-Methoxyisoquinoline (CAS: 39989-39-4) typically synthesized?

7-Methoxyisoquinoline (CAS: 39989-39-4) is typically synthesized via the methylation of isoquinoline followed by an oxygenation reaction. Common methods involve the use of methyl bromide and a suitable base in an aprotic solvent, followed by treatment with a peroxyacid to introduce the oxygen functionality. The overall yield can be up to 80%, and the reaction is selective with high purity products. Catalytic hydrogenation can also be used to modify the product further.