Compound Q&A

How is 5-Methoxy-1H-indazole (CAS: 94444-96-9) typically synthesized?

Answer

5-Methoxy-1H-indazole
5-Methoxy-1H-indazole is typically synthesized via the methylation of indazole or its intermediates. Common methods include the reaction of indazole with methanol in the presence of a base, such as potassium hydroxide, followed by acidification to obtain the desired methoxy derivative. Other synthetic routes involve the use of methylation reagents like dimethyl sulfate or methyl iodide, often catalyzed by Lewis acids, to selectively introduce the methoxy group into the indazole ring.

About

CAS No 94444-96-9
English Name 5-Methoxy-1H-indazole
Molecular Formula C8H8N2O
Molecular Weight 148.17 g/mol
SMILES COC1=CC2=C(C=C1)NN=C2
InChIKey GZWWDKIVVTXLFL-UHFFFAOYSA-N
Last Updated: 2025-10-08 00:58

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