Compound Q&A
How is (3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (CAS: 129273-38-7) typically synthesized?
Answer
![(3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)](https://static.chemtradehub.com/structs/129/129273-38-7-98b8.webp "(3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)")
(3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride can be synthesized by a multi-step process involving piperazine, benzothiazole, and 2-butylhexahydroisoindole. The synthesis typically requires the use of a catalyst such as triethylamine and proceeds under conditions of low to moderate temperature, with a yield of approximately 75-85%. The product is then isolated by crystallization and recrystallization to enhance its purity.
About
CAS No
129273-38-7
English Name
(3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)
Molecular Formula
C23H31ClN4O2S
Molecular Weight
463.05 g/mol
SMILES
C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54.Cl
InChIKey
HIZFAPMOZFYELI-GNXQHMNLSA-N
Last Updated: 2025-10-07 19:42
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