Compound Q&A
How is 1-Methyl-3-(trifluoromethyl)benzene (CAS: 401-79-6) typically synthesized?
Answer
1-Methyl-3-(trifluoromethyl)benzene (CAS: 401-79-6) is typically synthesized through Friedel-Crafts alkylation of benzene with trifluoroacetamide and aluminum chloride as a catalyst. The reaction provides high selectivity and yield, making it a common method for preparing this compound. Other methods include Friedel-Crafts alkylations with other trifluoromethylating agents like trifluoromethylsulfonyl chloride.
About
CAS No
401-79-6
English Name
1-Methyl-3-(trifluoromethyl)benzene
Molecular Formula
C8H7F3
Molecular Weight
160.14 g/mol
SMILES
CC1=CC(=CC=C1)C(F)(F)F
InChIKey
VJYXZJGDFJJDGF-UHFFFAOYSA-N
Last Updated: 2025-10-07 19:42
