Compound Q&A

Are there alternatives to 1-Chloro-4-(trifluoromethoxy)benzene (CAS: 461-81-4) in synthesis?

Answer

1-Chloro-4-(trifluoromethoxy)benzene
Alternative reagents such as 4-(trifluoromethoxy)benzenesulfonic acid or 2-chloro-4-(trifluoromethoxy)benzene can be used as substitutes in synthesis. These alternatives offer similar functional groups but with different steric and electronic properties. Careful consideration of chemical properties and reaction conditions is essential when choosing an alternative.

About

CAS No 461-81-4
English Name 1-Chloro-4-(trifluoromethoxy)benzene
Molecular Formula C7H4ClF3O
Molecular Weight 196.56 g/mol
SMILES C1=CC(=CC=C1OC(F)(F)F)Cl
InChIKey SELFZOLQRDPBKC-UHFFFAOYSA-N
Last Updated: 2025-10-06 07:30

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