Compound Q&A
How is 1-N-Boc-3-cyanopiperidine (CAS: 91419-53-3) typically synthesized?
Answer
1-N-Boc-3-cyanopiperidine is typically synthesized from 3-cyanopiperidine and Boc2O ( tert-Butyloxycarbonyl chloride) in the presence of a base such as diisopropylethylamine (DIPEA). The reaction involves the formation of a tert-butyl ester derivative, which is then purified by recrystallization or column chromatography. The yield is usually high, around 85-90%.
About
CAS No
91419-53-3
English Name
1-N-Boc-3-cyanopiperidine
Molecular Formula
C11H18N2O2
Molecular Weight
199.29 g/mol
SMILES
CC(C)(C)OC(=O)N1CCCC(C1)C#N
InChIKey
UEFZTXGFHKPSFS-UHFFFAOYSA-N
Last Updated: 2025-10-05 08:54
