Compound Q&A
How is 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine (CAS: 602306-29-6) typically synthesized?
Answer
![4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine](https://static.chemtradehub.com/structs/602/602306-29-6-e5ff.webp "4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine")
This compound can be synthesized via a multistep reaction involving the coupling of 4-(methylsulfonyl)aniline with 2-bromo-5-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidine under palladium-catalyzed conditions. The reaction proceeds with good yield and selectivity under optimized reaction conditions, including the use of Pd(PPh3)4 as a catalyst.
About
CAS No
602306-29-6
English Name
4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Molecular Formula
C18H21N5O2S
Molecular Weight
371.47 g/mol
SMILES
CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C
InChIKey
WJRRGYBTGDJBFX-UHFFFAOYSA-N
Last Updated: 2025-10-01 21:42
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