Compound Q&A

How is rac-(1R,2R)-cyclopentane-1,2-dicarboxylic acid (CAS: 1461-97-8) typically synthesized?

Answer

rac-(1R,2R)-cyclopentane-1,2-dicarboxylic acid
Rac-(1R,2R)-cyclopentane-1,2-dicarboxylic acid (CAS: 1461-97-8) can be synthesized via the Wittig reaction or by the acylation of cyclopentanone with acetic anhydride. The Wittig reaction involves the use of an organophosphorus reagent to form the cyclic ester, which is then converted to the dicarboxylic acid. The acylation method yields a racemic mixture with good yield and selectivity.

About

CAS No 1461-97-8
English Name rac-(1R,2R)-cyclopentane-1,2-dicarboxylic acid
Molecular Formula C7H10O4
Molecular Weight 158.15 g/mol
SMILES C1CC(C(C1)C(=O)O)C(=O)O
InChIKey ASJCSAKCMTWGAH-RFZPGFLSSA-N
Last Updated: 2025-10-01 13:51

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