Compound Q&A
How is 3-Chloro-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-phenylalanine (CAS: 80102-25-6) typically synthesized?
Answer
![3-Chloro-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-phenylalanine](https://static.chemtradehub.com/structs/801/80102-25-6-f6b2.webp "3-Chloro-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-phenylalanine")
This compound can be synthesized via a multi-step reaction involving the protection of D-phenylalanine, followed by the installation of a chloro group and subsequent acylation with a 2-methyl-2-propanol derivative. Commonly used catalysts include HOBt and DCC, and the reaction is typically carried out in anhydrous organic solvents like dichloromethane under nitrogen atmosphere. The yield is generally around 70-80%, and the selectivity is high.
About
CAS No
80102-25-6
English Name
3-Chloro-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-phenylalanine
Molecular Formula
C14H18ClNO4
Molecular Weight
299.75 g/mol
SMILES
CC(C)(C)OC(=O)NC(CC1=CC(=CC=C1)Cl)C(=O)O
InChIKey
RCZHBTHQISEPPP-LLVKDONJSA-N
Last Updated: 2025-09-29 09:43
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