How is N~1~-{(2S,3R)-3-Hydroxy-4-[(3S,4aS,8aS)-3-[(2-methyl-2-propanyl)carbamoyl]octahydro-2(1H)-isoquinolinyl]-1-phenyl-2-butanyl}-N~2~-(2-quinolinylcarbonyl)-L-aspartamide (CAS: 127779-20-8) typically synthesized?

This compound is synthesized via a multistep process involving amidation and condensation reactions. The key steps include the formation of an intermediate amide through the coupling of a quinoline carboxylic acid and a phenyl-L-aspartamide, followed by the installation of the complex side chain via a Wittig reaction. The overall yield is moderate, and the reaction is typically carried out under anhydrous conditions using a suitable catalyst.