Compound Q&A

How is 2-Chloro-6-fluorophenol (CAS: 2040-90-6) typically synthesized?

Answer

2-Chloro-6-fluorophenol
2-Chloro-6-fluorophenol is typically synthesized via the electrophilic aromatic substitution of 6-fluorophenol with chlorine in the presence of a Lewis acid catalyst, such as aluminum chloride (AlCl3). The reaction is performed in an inert organic solvent at a moderate temperature, resulting in a high yield of the product. The process is selective and efficient, making it a common method for industrial scale production.

About

CAS No 2040-90-6
English Name 2-Chloro-6-fluorophenol
Molecular Formula C6H4ClFO
Molecular Weight 146.54799999999997 g/mol
SMILES C1=CC(=C(C(=C1)Cl)O)F
InChIKey QIAQIYQASAWZPP-UHFFFAOYSA-N
Last Updated: 2025-09-29 09:43

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