How is (1R,3S,4S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (CAS: 291775-59-2) typically synthesized?

(1R,3S,4S)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[2.2.1]heptane-3-carboxylic acid is synthesized through multistep reactions involving protected azabicyclic structures, followed by deprotection and functional group manipulation. Common methods include using protecting groups such as tert-butyldimethylsilyl (TBS) groups and employing Lewis acids like trifluoromethanesulfonic anhydride (TFMSA) for the introduction of the carbonyl functionality. The overall yield is typically around 70-80%. This synthesis requires careful control of conditions to achieve the desired stereochemistry.