How is 4,6-Dichloro-5-fluoropyrimidine (CAS: 213265-83-9) typically synthesized?

4,6-Dichloro-5-fluoropyrimidine is typically synthesized via the reaction of 5-fluorouracil with chloracetyl chloride in the presence of a base such as sodium hydroxide. The reaction yields a mixture rich in 4,6-dichloro-5-fluoropyrimidine with a high degree of selectivity. The yield is typically around 80-90%, and the method uses common laboratory equipment and standard techniques.