How is N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydro-4-acridinecarboxamide (CAS: 143664-11-3) typically synthesized?

N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydro-4-acridinecarboxamide is usually synthesized through a multistep process involving the coupling of an acridone derivative with a 6,7-dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl ethylamine under mild conditions. The reaction is typically catalyzed by a palladium complex and proceeds with good yield and selectivity.