Compound Q&A
Are there alternatives to Monomethyl Auristatin F (CAS: 745017-94-1) in synthesis?
Answer
Monomethyl Auristatin F (MMAF) is a potent cytotoxic agent but alternatives such as monomethyl auristatin E (MMAE) and pyrrolobenzodiazepines (PBDs) are used in some synthesis processes. These alternatives offer similar anti-cancer properties and can be used as substitutes depending on the specific requirements of the synthesis and the desired pharmacological profile.
About
CAS No
745017-94-1
English Name
Monomethyl Auristatin F
Molecular Formula
C39H65N5O8
Molecular Weight
731.98 g/mol
SMILES
CN[C@H](C(=O)N[C@H](C(=O)N(C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C
InChIKey
MFRNYXJJRJQHNW-DEMKXPNLSA-N
Last Updated: 2025-09-27 00:43
