How is 4-Methylpentanoyl chloride (CAS: 38136-29-7) typically synthesized?

4-Methylpentanoyl chloride is typically synthesized by the reaction of 4-methylpentanoic acid with thionyl chloride. This process yields a high yield of the desired product. The reaction is usually carried out under anhydrous conditions to prevent hydrolysis and is catalyzed by thionyl chloride. The reaction is exothermic and requires careful temperature control to avoid side reactions.