Compound Q&A
How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine (CAS: 77128-73-5) typically synthesized?
Answer
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N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine is typically synthesized via a multi-step process involving the coupling of fluorenylmethoxycarbonyl (Fmoc) protected L-phenylalanine with methylamine followed by deprotection. The synthesis requires the use of coupling reagents like HATU or DIC, and the reaction is typically carried out in an organic solvent such as DMF with a catalytic amount of a base like DIPEA. The yield and selectivity can be optimized by adjusting reaction conditions and protecting group choice.
About
CAS No
77128-73-5
English Name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine
Molecular Formula
C25H23NO4
Molecular Weight
401.46 g/mol
SMILES
CN(C(CC1=CC=CC=C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
InChIKey
GBROUWPNYVBLFO-QHCPKHFHSA-N
Last Updated: 2025-09-25 13:48
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