Compound Q&A

How is 4-Methyl-2-pyrimidinamine (CAS: 108-52-1) typically synthesized?

Answer

4-Methyl-2-pyrimidinamine
4-Methyl-2-pyrimidinamine can be synthesized through the condensation of 4-methylpyrimidine with formaldehyde in the presence of a strong acid catalyst. The reaction is carried out at room temperature and yields up to 85% of the product. The selectivity and yield can be improved by using appropriate reaction conditions and optimizing the catalyst type.

About

CAS No 108-52-1
English Name 4-Methyl-2-pyrimidinamine
Molecular Formula C5H7N3
Molecular Weight 109.13 g/mol
SMILES CC1=NC(=NC=C1)N
InChIKey GHCFWKFREBNSPC-UHFFFAOYSA-N
Last Updated: 2025-09-23 10:23

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