Compound Q&A

How is 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone (CAS: 4176-97-0) typically synthesized?

Answer

3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone
This compound can be synthesized via a condensation reaction between a naphthoquinone derivative and a furanone, followed by reduction of the ketone to an aldehyde. Commonly used catalysts include palladium-based catalysts, and the reaction is typically achieved with a yield of about 70-80%. The synthetic route involves several steps and requires careful control of reaction conditions to achieve high purity.

About

CAS No 4176-97-0
English Name 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone
Molecular Formula C20H30O4
Molecular Weight 334.46 g/mol
SMILES CC12CCC(C(C1CCC(=C)C2CCC3=CCOC3=O)(C)CO)O
InChIKey GVRNTWSGBWPJGS-YSDSKTICSA-N
Last Updated: 2025-09-22 19:21

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