Compound Q&A

How is Amifostine Trihydrate (CAS: 112901-68-5) typically synthesized?

Answer

Amifostine Trihydrate
Amifostine trihydrate is synthesized through a multi-step process involving the formation of amifostine from ethyl 4-((2-aminoethoxy)methyl)-2,2-dimethyl-1,3-propanediol and its subsequent hydration to form the trihydrate form. The synthesis typically involves esterification, reduction, and dehydration steps, with high yield and selectivity.

About

English Name Amifostine Trihydrate
Molecular Formula C5H21N2O6PS
Molecular Weight 268.27 g/mol
SMILES C(CN)CNCCSP(=O)(O)O.O.O.O
InChIKey TXQPXJKRNHJWAX-UHFFFAOYSA-N
Last Updated: 2025-09-13 09:53

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