Compound Q&A
How is N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide (CAS: 101463-69-8) typically synthesized?
Answer
![N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide](https://static.chemtradehub.com/structs/101/101463-69-8-8922.webp "N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide")
N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide is synthesized via a multi-step process involving the coupling of 2,6-difluorobenzamide with an appropriate amino acid derivative. Commonly, the synthesis involves the use of a coupling reagent such as HATU and a base like diisopropylethylamine. The process yields a high purity product with good selectivity and a yield of around 70-75%.
About
CAS No
101463-69-8
English Name
N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide
Molecular Formula
C21H11ClF6N2O3
Molecular Weight
488.77 g/mol
SMILES
C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=C(C=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)Cl)F)F
InChIKey
RYLHNOVXKPXDIP-UHFFFAOYSA-N
Last Updated: 2025-09-13 09:53
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