Compound Q&A
How is (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid (CAS: 287714-41-4) typically synthesized?
Answer
![(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid](https://static.chemtradehub.com/structs/287/287714-41-4-93b3.webp "(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid")
The compound is typically synthesized via a multi-step process involving the condensation of a fluorophenyl derivative with a pyrimidine intermediate, followed by the coupling of a propan-2-yl group and the introduction of a 3,5-dihydroxyhept-6-enoic acid moiety. Commonly used catalysts include phosphine-based ligands and palladium complexes. The synthetic route ensures high selectivity and yield, often achieving over 90% product purity.
About
CAS No
287714-41-4
English Name
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
Molecular Formula
C22H28FN3O6S
Molecular Weight
481.55 g/mol
SMILES
CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
InChIKey
BPRHUIZQVSMCRT-VEUZHWNKSA-N
Last Updated: 2025-09-10 15:15
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