Compound Q&A
How is N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine (CAS: 379231-04-6) typically synthesized?
Answer
![N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine](https://static.chemtradehub.com/structs/379/379231-04-6-897c.webp "N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine")
The compound is synthesized using a multi-step process involving the coupling of 5-chloro-1,3-benzodioxol-4-amine with a piperazine derivative, followed by the introduction of a tetrahydro-2H-pyran group and a quinazoline ring. Common catalysts include triphenylphosphine and palladium. The final product is typically obtained with high yield and selectivity.
About
CAS No
379231-04-6
English Name
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine
Molecular Formula
C27H32ClN5O5
Molecular Weight
542.04 g/mol
SMILES
CN1CCN(CC1)CCOC2=CC3=C(C(=C2)OC4CCOCC4)C(=NC=N3)NC5=C(C=CC6=C5OCO6)Cl
InChIKey
OUKYUETWWIPKQR-UHFFFAOYSA-N
Last Updated: 2025-09-10 15:15
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