Compound Q&A

How is 4,4,4-Trifluorobutanoic acid (CAS: 406-93-9) typically synthesized?

Answer

4,4,4-Trifluorobutanoic acid
4,4,4-Trifluorobutanoic acid is typically synthesized via the reaction of trifluoroacetyl chloride with 1-butanol in the presence of a base like sodium hydride. The process involves the stepwise formation of an acetoxy derivative followed by hydrolysis to form the carboxylic acid. The yield can be up to 80%, with good selectivity towards the desired product.

About

CAS No 406-93-9
English Name 4,4,4-Trifluorobutanoic acid
Molecular Formula C4H5F3O2
Molecular Weight 142.08 g/mol
SMILES C(CC(F)(F)F)C(=O)O
InChIKey WTUCTMYLCMVYEX-UHFFFAOYSA-N
Last Updated: 2025-09-09 19:18

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