How is (3R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-piperidinecarboxylic acid (CAS: 163438-09-3) typically synthesized?

(3R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-piperidinecarboxylic acid is usually synthesized via a multi-step process involving the protection of the piperidine ring, followed by acylation of the alcohol group, and subsequent deprotection. Commonly, this involves the use of a protected piperidine, acylation with an acyl chloride in the presence of a base, and then removal of the protecting group. This synthesis generally yields a high purity product with good selectivity.