Compound Q&A
How is 4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid (CAS: 1028486-01-2) typically synthesized?
Answer
![4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid](https://static.chemtradehub.com/structs/102/1028486-01-2-9b19.webp "4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid")
The compound is typically synthesized through a multi-step process involving the synthesis of the pyrimido[5,4-d][2]benzazepin-2-ylamine, followed by coupling with the 2-methoxybenzoic acid derivative. The reaction is catalyzed by a suitable transition metal complex, such as palladium, and proceeds under mild conditions to achieve good selectivity and yield.
About
CAS No
1028486-01-2
English Name
4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
Molecular Formula
C27H20ClFN4O4
Molecular Weight
518.93 g/mol
SMILES
COc1cccc(c1C1=NCc2c(c3c1cc(Cl)cc3)nc(nc2)Nc1ccc(c(c1)OC)C(=O)O)F
InChIKey
ZLHFILGSQDJULK-UHFFFAOYSA-N
Last Updated: 2025-09-09 19:18
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