Compound Q&A

How is N-{4-[(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide (CAS: 150683-30-0) typically synthesized?

Answer

N-{4-[(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
N-{4-[(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide (CAS: 150683-30-0) is synthesized through a multi-step process involving the condensation of 7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine with 2-methylbenzoic acid. The reaction is typically catalyzed by a mild acid and proceeds with high selectivity and good yield. The key steps include the formation of an intermediate ester, followed by condensation and deprotection.

About

English Name N-{4-[(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
Molecular Formula C26H25ClN2O3
Molecular Weight 448.95 g/mol
SMILES CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
InChIKey GYHCTFXIZSNGJT-UHFFFAOYSA-N
Last Updated: 2025-09-09 08:06

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