Compound Q&A
How is (2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one (CAS: 26328-04-1) typically synthesized?
Answer
![(2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one (2Z)-2-butenedioate (1:1)](https://static.chemtradehub.com/structs/263/26328-04-1-0648.webp "(2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one (2Z)-2-butenedioate (1:1)")
The compound is typically synthesized via a multi-step process involving the condensation of 3,4,5-trimethoxybenzaldehyde with N-oxo-1-pyrrolidine ethylamine, followed by the coupling with 1-piperazine-1-carboxylic acid. The synthesis requires water-solvent mixtures and is optimized using mild conditions to achieve a yield of around 70-80%.
About
CAS No
26328-04-1
English Name
(2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one (2Z)-2-butenedioate (1:1)
Molecular Formula
C26H35N3O9
Molecular Weight
533.58 g/mol
EINECS
247-613-1
SMILES
COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O
InChIKey
XSTJTOKYCAJVMJ-GVTSEVKNSA-N
Last Updated: 2025-09-08 00:42