How is disodium;(6R,7R)-7-[[2-carboxylato-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (CAS: 64953-12-4) typically synthesized?

Disodium;(6R,7R)-7-[[2-carboxylato-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is synthesized through multi-step organic reactions, involving coupling, condensation, and esterification. Commonly, a Wittig reaction followed by a tetrazole formation and an amide coupling are used. The reaction conditions include the use of triphenylphosphine and N,N-dimethylformamide as solvents, with temperatures ranging from room temperature to reflux. Yield and selectivity are around 70-80%.