Compound Q&A
How is 1-(4-Bromophenyl)-2,2,2-trifluoroethanone (CAS: 16184-89-7) typically synthesized?
Answer
1-(4-Bromophenyl)-2,2,2-trifluoroethanone is typically synthesized by the condensation of 4-bromophenol with trifluoroacetic anhydride. This process is often catalyzed by a Lewis acid such as aluminum trichloride. The reaction proceeds via nucleophilic aromatic substitution and acyloin condensation, yielding high yields and good selectivity. Careful control of reaction conditions is essential to achieve the desired product.
About
CAS No
16184-89-7
English Name
1-(4-Bromophenyl)-2,2,2-trifluoroethanone
Molecular Formula
C8H4BrF3O
Molecular Weight
253.02 g/mol
SMILES
C1=CC(=CC=C1C(=O)C(F)(F)F)Br
InChIKey
IHGSAQHSAGRWNI-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:19
