Compound Q&A
How is 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine (CAS: 72537-17-8) typically synthesized?
Answer
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine can be synthesized via the Friedel-Crafts alkylation of 2-fluoro-5-(trifluoromethyl)pyridine with chloroform, catalyzed by aluminum chloride. The reaction is carried out in dichloromethane or another suitable solvent. The yield of the product is typically around 70-80%, and the reaction is carefully controlled to achieve high selectivity and purity.
About
CAS No
72537-17-8
English Name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Molecular Formula
C6H2ClF4N
Molecular Weight
199.53 g/mol
SMILES
C1=C(C=NC(=C1Cl)F)C(F)(F)F
InChIKey
GDSROTVTTLUHCO-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:19
